Which agent is a nonsedating antihistamine

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Cetirizine is a metabolite of hydroxyzine and a selective peripheral histamine H1-receptor antagonist.

The following features are possibly relevant to efficacy: neutralization of circulating myelin antibodies through anti-idiotypic antibodies; down-regulation of proinflammatory cytokines, including IFN-gamma; blockade of Fc receptors on macrophages; suppression of inducer T and B cells and augmentation of T-suppressor cells; blockade of complement cascade; promotion of remyelination; and 10% increase in CSF Ig G.IVIG is currently the most common agent used to treat TEN.Cyclosporine may also have a role in the treatment of TEN.Antihistamines are used in the treatment of allergic reactions, colds, hay fever, hives, and insect bites and stings.Some antihistamines may also be helpful in reducing anxiety, inducing sleep, or at preventing or treating motion sickness.They're usually divided into two main groups: They also come in several different forms – including tablets, capsules, liquids, syrups, creams, lotions, gels, eye drops and nasal sprays.

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